We formalize a ramification theory for finite covers of knot exteriors. Given a knot group and a finite-index subgroup , we define meridional inertia subgroups and the global ramification subgroup as their normal closure. We then analyze from three complementary viewpoints: (1) finite quotients, where is shown to be the universal maximal meridionally unramified'' quotient of $U$; (2) profinite completions, where we identify the closed ramification subgroup $\widehat M_{\widehat U}$ as the closed normal subgroup generated by closed inertia and prove that meridian-preserving isomorphisms of profinite completions preserve inertia and ramification; (3) cohomology, where unramified’’ -classes (discrete and profinite) are characterized as those vanishing on all inertia subgroups, in direct analogy with number-theoretic inertia conditions in Galois cohomology.

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