Let be a totally real number field of odd degree in which is inert. Let be a prime with and . We prove that if is inert in , is non-Wieferich, i.e., , and is totally ramified in , then the asymptotic Fermat’s Last Theorem holds over each -th layer of the cyclotomic -extension of . We then prove that the generalized Fermat equation has no asymptotic solution over each -th layer when . For any odd prime , we also prove that if and is odd, then the generalized Fermat equation has no effective asymptotic solution with . The effectivity in the case of follows from a result of Thorne proving the modularity of elliptic curves over .

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